IN SILICO ANALYSIS REVEALED FIVE NOVEL HIGH-RISK SINGLE-NUCLEOTIDE POLYMORPHISMS (RS200384291, RS201163886, RS193141883, RS201139487, AND RS201723157) IN ELANE GENE CAUSING AUTOSOMAL DOMINANT SEVERE CONGENITAL NEUTROPENIA 1 AND CYCLIC HEMATOPOIESIS

Single-nucleotide polymorphisms in the ELANE (Elastase, Neutrophil Expressed) gene are associated with severe congenital neutropenia, while the ELANE gene provides instructions for making a protein called neutrophil elastase.We identified disease susceptibility single-nucleotide polymorphisms (SNPs) in the ELANE gene using several computational Bre

Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear.Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/IGF-1 and glp-1/Notch mutants In

Abstract We study the probability that a horizon appears when concentric shells of matter collide, by computing the horizon wave-function of the system.We mostly consider the collision of wood dpn two ultra-relativistic shells, both shrinking and expanding, at the moment their radii are equal, and find a probability that the system is a black hole

ARTHRI-PLUS CREME The drilling of carbon fiber reinforced plastics (CFRP) is a significant topic for the aircraft industry.However, CFRP are materials which are difficult to cut due to their unique properties.This paper studies tools with excellent cutting performance in machining CFRP.The microcrystalline diamond (MCD), nanocrystalline diamond (NC